CovidV1, Main, Exploration, bibRecord, 001022

A serological survey on neutralizing antibody titer of SARS convalescent sera

Identifieur interne : 001022 ( Main/Exploration ); précédent : 001021; suivant : 001023

A serological survey on neutralizing antibody titer of SARS convalescent sera

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2005-10.

RBID : ISTEX:F066BD559402A5F38564C58EA794B07017CF14D3

English descriptors

Teeft :
- Antibody, Assay, Beijing, Convalescent, Convalescent sera, Coronavirus, Elisa, Hebei province, Immunosorbent assay, Inner mongolia, Neutralization, Neutralization assay, Neutralizing, Neutralizing antibody titer, Normal distribution, Passive transfer, Positive sera, Respiratory syndrome, Sars, Sars cases, Sars convalescent sera, Sars patients, Sars vaccine, Serum samples, Syndrome, Titer, Vaccine, Vero cells, Western blot.

Abstract

A seroepidemiologic study was conducted in North China in 2003 to determine the neutralizing antibody titer of severe acute respiratory syndrome (SARS) convalescent sera. A total of 99 SARS convalescent serum samples were collected from patients from the Inner Mongolia Autonomous Region, Hebei Province, and Beijing 35–180 days after the onset of symptoms. The anti‐SARS antibodies were detected by enzyme‐linked immunosorbent assay (ELISA), neutralization assay, and Western blot. Eighty‐seven serum samples were confirmed to be positive for SARS antibodies. The neutralizing antibody titer of the 87 positive sera was analyzed quantitatively by neutralization assay. The geometric mean titer (GMT) of the 87 convalescent sera was 1:61. The Kolmogorov–Smirnov test showed that the neutralizing antibody titers conform to normal distribution, which suggests that the average anti‐SARS antibody level in this study was representative of the convalescent antibody level of the SARS population. This result could be useful for the development and quality control of SARS vaccines. J. Med. Virol. 77:147–150, 2005. © 2005 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/ark:/67375/WNG-CTTG3L81-5/fulltext.pdf

DOI: 10.1002/jmv.20431

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Liu, Yu Uan" sort="Liu, Yu Uan" uniqKey="Liu Y" first="Yu-Xuan" last="Liu">Yu-Xuan Liu</name>
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<author><name sortKey="Zhang, Zhen Han" sort="Zhang, Zhen Han" uniqKey="Zhang Z" first="Zhen-Shan" last="Zhang">Zhen-Shan Zhang</name>
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<author><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name>
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<author><name sortKey="Gao, Qiang" sort="Gao, Qiang" uniqKey="Gao Q" first="Qiang" last="Gao">Qiang Gao</name>
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<author><name sortKey="Xu, Jian Uo" sort="Xu, Jian Uo" uniqKey="Xu J" first="Jian-Guo" last="Xu">Jian-Guo Xu</name>
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<author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name>
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<author><name sortKey="Dong, Xiao Ing" sort="Dong, Xiao Ing" uniqKey="Dong X" first="Xiao-Ping" last="Dong">Xiao-Ping Dong</name>
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<term>Coronavirus</term>
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<front><div type="abstract" xml:lang="en">A seroepidemiologic study was conducted in North China in 2003 to determine the neutralizing antibody titer of severe acute respiratory syndrome (SARS) convalescent sera. A total of 99 SARS convalescent serum samples were collected from patients from the Inner Mongolia Autonomous Region, Hebei Province, and Beijing 35–180 days after the onset of symptoms. The anti‐SARS antibodies were detected by enzyme‐linked immunosorbent assay (ELISA), neutralization assay, and Western blot. Eighty‐seven serum samples were confirmed to be positive for SARS antibodies. The neutralizing antibody titer of the 87 positive sera was analyzed quantitatively by neutralization assay. The geometric mean titer (GMT) of the 87 convalescent sera was 1:61. The Kolmogorov–Smirnov test showed that the neutralizing antibody titers conform to normal distribution, which suggests that the average anti‐SARS antibody level in this study was representative of the convalescent antibody level of the SARS population. This result could be useful for the development and quality control of SARS vaccines. J. Med. Virol. 77:147–150, 2005. © 2005 Wiley‐Liss, Inc.</div>
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<name sortKey="Wang, Xu" sort="Wang, Xu" uniqKey="Wang X" first="Xu" last="Wang">Xu Wang</name>
<name sortKey="Xu, Jian Uo" sort="Xu, Jian Uo" uniqKey="Xu J" first="Jian-Guo" last="Xu">Jian-Guo Xu</name>
<name sortKey="Yin, Wei Ong" sort="Yin, Wei Ong" uniqKey="Yin W" first="Wei-Dong" last="Yin">Wei-Dong Yin</name>
<name sortKey="Yin, Wei Ong" sort="Yin, Wei Ong" uniqKey="Yin W" first="Wei-Dong" last="Yin">Wei-Dong Yin</name>
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A serological survey on neutralizing antibody titer of SARS convalescent sera

A serological survey on neutralizing antibody titer of SARS convalescent sera

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri